Summary

Name FCGR2B
Full Name Low affinity immunoglobulin gamma Fc region receptor II-b
Synonyms IgG Fc receptor II-b, CDw32, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b | CD32, FCG2, IGFR2
Primary ID P31994
Links - -
Type protein
Relations 4
Function Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation FCGR2B 0.443
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png TLR4 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png FCGR2B 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FCGR2B 0.2
Publications: 1 Organism: Homo Sapiens