Summary

Name MSX2
Full Name Homeobox protein MSX-2
Synonyms Homeobox protein Hox-8 | HOX8
Primary ID P35548
Links - -
Type protein
Relations 5
Function Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding MSX2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding DLX2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding DLX5
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MSX2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding SPEN 0.48
Publications: 1 Organism: Homo Sapiens