| + |
PBXIP1 | down-regulates activity 
binding
|
PBX2 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273667 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24488098 |
This protein that we have termed hematopoietic PBX-interacting protein (HPIP) is mainly localized in the cytosol and in small amounts in the nucleus. The region of PBX that interacts with HPIP includes both the homeodomain and immediate N-terminal flanking sequences. Strikingly, electrophoretic mobility shift assays revealed that HPIP inhibits the ability of PBX-HOX heterodimers to bind to target sequences. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PBX2 | down-regulates quantity by repression
transcriptional regulation
|
FGF8 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265778 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265804 |
|
|
Mus musculus |
CCE Cell |
| pmid |
sentence |
| 10026229 |
Our results in ES cells suggest that Engrailed inhibits Fgf8 expression in the absence of Pbx1. We identified single Engrailed- and Pbx-binding sites in the Fgf8 intron that inhibit expression of Fgf8 in mouse ES cells, but that together can allow full Fgf8 expression. Our data support the model that Engrailed heterodimerized with Pbx might activate transcription, while Engrailed or Pbx proteins alone might repress transcription |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
PBX2 | up-regulates quantity by expression 
transcriptional regulation
|
EMX2 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254466 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15494461 |
EMSA demonstrated HOXA10-Pbx2 binding as a heterodimer to an enhancer of the EMX2 gene, a known target of HOXA10 regulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PBX2
- 
- 