Summary

Name GRM5
Full Name Metabotropic glutamate receptor 5
Synonyms mGluR5 | GPRC1E, MGLUR5
Primary ID P41594
Links - -
Type protein
Relations 20
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.427
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.426
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.376
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.352
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.406
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.294
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.36
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding GNAS 0.338
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ up-regulates activity img/direct-activation.png chemical activation GRM5 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation GRM5 0.8
Publications: 1 Organism: Homo Sapiens