Summary

Name GATA4
Full Name Transcription factor GATA-4
Synonyms GATA-binding factor 4
Primary ID P43694
Links - -
Type protein
Relations 14
Function Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA4 0.461
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GATA4 0.775
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GATA4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA4 0.518
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding GATA4 0.47
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GATA4 0.845
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HAMP 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA4 0.419
Publications: 1 Organism: Drosophila Melanogaster
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TDO2 0.256
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation α-Catenin 0.254
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CTNNA3 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GATA4 0.2
Publications: 1 Organism: Drosophila Melanogaster