Summary

Name SLC11A1
Full Name Natural resistance-associated macrophage protein 1
Synonyms NRAMP 1, Solute carrier family 11 member 1 | LSH, NRAMP, NRAMP1
Primary ID P49279
Links - -
Type protein
Relations 3
Function Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png M1_polarization 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SLC11A1 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png SLC11A1 0.359
Publications: 1 Organism: Homo Sapiens