Summary

Name FASN
Full Name Fatty acid synthase
Synonyms FAS_HUMAN | FAS
Primary ID P49327
Links - -
Type protein
Relations 23
Pathways Circadian clock, Fatty Acid Synthesis
Function Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FASN 0.503
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates img/indirect-activation.png Lipogenesis 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png WNT1 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png acetylation FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification NADP(3-) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification NADPH(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates img/indirect-activation.png Fatty_Acid_Biosynthesis 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity img/direct-activation.png chemical modification coenzyme A(4-) 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification malonyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/indirect-activation.png CTNNB1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification hexadecanoic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ down-regulates quantity img/direct_inhibition.png chemical modification acetyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png binding FASN 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification long-chain fatty acid anion 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png chemical activation FASN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png deacetylation FASN 0.2
Publications: 1 Organism: Homo Sapiens