Summary

Name FHIT
Full Name Bis
Synonyms AP3A hydrolase, AP3Aase, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, Dinucleosidetriphosphatase, Fragile histidine triad protein
Primary ID P49789
Links - -
Type protein
Relations 11
Pathways Pancreatic ductal adenocarcinoma (PDA)
Function Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation FHIT 0.482
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.528
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/indirect_inhibition.png AKT 0.387
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MMP14 0.284
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BIRC5 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AKT1 0.387
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png AKT2 0.253
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AXIN2 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MDM2 0.441
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ up-regulates img/indirect-activation.png TP53 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Pancreatic ductal adenocarcinoma (PDA)
+ down-regulates img/indirect_inhibition.png AKT3 0.253
Publications: 1 Organism: Homo Sapiens