Summary

Name AFDN
Full Name Afadin
Synonyms ALL1-fused gene from chromosome 6 protein, Protein AF-6 | AF6
Primary ID P55196
Links - -
Type protein
Relations 2
Function Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (PubMed:11024295). May play a key role in the organization of epithelial structures of the embryonic ectoderm (By similarity). Essential for the organization of adherens junctions (PubMed:30463011).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding RIT1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RIN1 0.2
Publications: 1 Organism: Homo Sapiens