Summary

Name DLX5
Full Name Homeobox protein DLX-5
Synonyms DLX5_HUMAN
Primary ID P56178
Links - -
Type protein
Relations 13
Pathways FAP: BMP
Function Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding DLX5
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding DLX5
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation SPP1
Publications: 1 Organism: Gallus Gallus
+ down-regulates activity img/direct_inhibition.png binding MSX2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MSX1
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation DLX5 0.08
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DLX5
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX2
Publications: 2 Organism: Homo Sapiens
Pathways:FAP: BMP
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DLX5 0.46
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation MYC 0.05
Publications: 1 Organism: Homo Sapiens