Summary

Name TIRAP
Full Name Toll/interleukin-1 receptor domain-containing adapter protein
Synonyms TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2 | MAL
Primary ID P58753
Links - -
Type protein
Relations 8
Pathways EBV infection, Innate Immune Response, Toll like receptors
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding TIRAP 0.458
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ up-regulates img/direct-activation.png binding TIRAP 0.772
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TIRAP 0.398
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TIRAP 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Innate Immune Response, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TIRAP 0.716
Publications: 1 Organism: Mus Musculus
Pathways:EBV infection
+ up-regulates activity img/direct-activation.png binding MYD88 0.616
Publications: 2 Organism: Homo Sapiens
Pathways:EBV infection, Innate Immune Response, Toll like receptors
+ up-regulates activity img/direct-activation.png binding TIRAP 0.772
Publications: 1 Organism: Homo Sapiens