Summary

Name EIF4A1
Full Name Eukaryotic initiation factor 4A-I
Synonyms eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1 | DDX2A, EIF4A
Primary ID P60842
Links - -
Type protein
Relations 3
Inhibitors Unii-2ewn8Z05CN
Function ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png chemical inhibition EIF4A1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding EIF4A1 0.863
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding EIF4A1 0.795
Publications: 1 Organism: In Vitro