| + |
NCS1 | down-regulates activity 
binding
|
GRK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263965 |
|
|
Homo sapiens |
HEK-293 Cell, Neuron |
| pmid |
sentence |
| 12351722 |
Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism that involves a reduction in D2 receptor phosphorylation. Coimmunoprecipitation experiments from striatal neurons reveal that NCS-1 is found in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 receptor desensitization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RAPL1 | up-regulates activity 
binding
|
NCS1 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263962 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 12783849 |
IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. our data show that IL1RAPL interacts only with NCS-1 through its specific C-terminal domain. The functional relevance of IL1RAPL activity was further supported by the inhibitory effect on exocytosis in PC12 cells overexpressing IL1RAPL. Taken together, our data suggest that IL1RAPL may regulate calcium-dependent exocytosis and provide insight into the understanding of physiopathological mechanisms underlying cognitive impairment resulting from IL1RAPL dysfunction. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NCS1 | down-regulates activity
binding
|
DRD2 |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263964 |
|
|
Homo sapiens |
HEK-293 Cell, Neuron |
| pmid |
sentence |
| 12351722 |
Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism that involves a reduction in D2 receptor phosphorylation. Coimmunoprecipitation experiments from striatal neurons reveal that NCS-1 is found in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 receptor desensitization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCS1 | up-regulates activity 
|
PI4KB |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263963 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 21104311 |
In chromaffin and PC12 cells, NCS-1 can enhance secretion via its activation of PI4 kinaseIIIb with the subsequent increase in PIP2 levels. PIP2 has been shown to be an important requirement for exocytosis |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
IL1RAPL2 | up-regulates activity
binding
|
NCS1 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264476 |
|
|
Rattus norvegicus |
PC-12 Cell |
| pmid |
sentence |
| 12783849 |
IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. our data show that IL1RAPL interacts only with NCS-1 through its specific C-terminal domain. The functional relevance of IL1RAPL activity was further supported by the inhibitory effect on exocytosis in PC12 cells overexpressing IL1RAPL. Taken together, our data suggest that IL1RAPL may regulate calcium-dependent exocytosis and provide insight into the understanding of physiopathological mechanisms underlying cognitive impairment resulting from IL1RAPL dysfunction. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
NCS1
- 
- 