Summary

Name ARF6
Full Name ADP-ribosylation factor 6
Synonyms ARF6_HUMAN
Primary ID P62330
Links - -
Type protein
Relations 10
Function GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity). Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png relocalization ARF6 0.646
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Neurite_outgrowth 0.7
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by destabilization img/direct_inhibition.png binding ARF6 0.698
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/indirect-activation.png Vesicle_transport 0.7
Publications: 1
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor ARF6 0.466
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor ARF6 0.883
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by destabilization img/direct_inhibition.png ARF6 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png PIP4K2A 0.342
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/indirect-activation.png Endocytosis 0.7
Publications: 1
+ up-regulates activity img/direct-activation.png gtpase-activating protein ARF6 0.654
Publications: 1 Organism: In Vitro