| + |
JAG1 | up-regulates 
binding
|
NOTCH2 |
0.619 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179622 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18660822 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72112 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10551863 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81364 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10958687 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression 
transcriptional regulation
|
JAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254348 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20953350 |
Contact with skip is required for biological activity of notchic. A mutation in the fourth ankyrin repeat that abolished notch signal transduction did not affect interaction with cbf1 but abolished interaction with skip. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG1 | up-regulates activity
binding
|
NOTCH1 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219253 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 18660822 |
We identify functional fragments of human notch-1 (n-1) and jagged-1 (j-1) which interact in a calcium-dependent manner. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| Pathways: | NOTCH Signaling |
| + |
SNAI2 | up-regulates quantity by expression
transcriptional regulation
|
JAG1 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255151 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20509143 |
SLUG up-regulation engenders breast cancer cells with stem cell-like properties including enhanced expression of CD44 and Jagged-1 in conjunction with estrogen receptor alpha down-regulation, growth as mammospheres, and extracellular matrix invasiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
A5/b1 integrin | up-regulates quantity by expression
transcriptional regulation
|
JAG1 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253288 |
|
|
Mus musculus |
Endothelial Progenitor Cell |
| pmid |
sentence |
| 25786978 |
First, EPCs incorporated into the neovascular region recognize the TGFBIp secreted by cells in the environment via binding to integrins a4 and a5. Second, binding of TGFBIp to integrins in EPCs induces phosphorylation of intracellular signaling molecules in a pathway necessary for TGFBIp-mediated angiogenic activity of EPCs. In addition, binding of TGFBIp to integrins activates the NF-kappaB signaling pathway that induces expression of DLL1 and JAG1 in EPCs. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
KDM4C | up-regulates quantity by expression
transcriptional regulation
|
JAG1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23698634 |
The expression of KDM4C gene was increased in spheres from colorectal cancer (CRC) cells and the knockdown (KD) of KDM4C eliminated colonosphere formation. KDM4C KD decreased the expression of JAG1 gene, and the downregulation of JAG1 gene recapitulated the impaired colonosphere formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIB1 | up-regulates activity
ubiquitination
|
JAG1 |
0.677 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-159480 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18043734 |
Mib1 is essential for the generation of functional notch ligands and regulates the classical notch ligands dll1, dll4, jag1, and jag2 in vertebrates mib1 is an essential e3 ubiquitin ligase for jag1 in the developing cerebellum. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97388 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12530964 |
Mib1 is essential for the generation of functional notch ligands and regulates the classical notch ligands dll1, dll4, jag1, and jag2 in vertebrates mib1 is an essential e3 ubiquitin ligase for jag1 in the developing cerebellum. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| Pathways: | NOTCH Signaling |
| + |
JAG2 | up-regulates
|
JAG1 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236888 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 9315665 |
Immunohistochemistry revealed coexpression of jagged2 and notch1 within thymus and other fetal murine tissues, consistent with interaction of the two proteins in vivo. Coculture of fibroblasts expressing human jagged2 with murine c2c12 myoblasts inhibited myogenic differentiation, accompanied by increased notch1 and the appearance of a novel 115-kda notch1 fragment. Exposure of c2c12 cells to jagged2 led to increased amounts of notch mrna as well as mrnas for a second notch receptor, notch3, and a second notch ligand, jagged1. Constitutively active forms of notchl in c2c12 cells also induced increased levels of the same set of mrnas, suggesting positive feedback control of these genes initiated by binding of jagged2 to notch1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
JAG1 | up-regulates
binding
|
NOTCH3 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18660822 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
A4/b1 integrin | up-regulates quantity by expression
transcriptional regulation
|
JAG1 |
0.309 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253287 |
|
|
Mus musculus |
Endothelial Progenitor Cell |
| pmid |
sentence |
| 25786978 |
First, EPCs incorporated into the neovascular region recognize the TGFBIp secreted by cells in the environment via binding to integrins a4 and a5. Second, binding of TGFBIp to integrins in EPCs induces phosphorylation of intracellular signaling molecules in a pathway necessary for TGFBIp-mediated angiogenic activity of EPCs. In addition, binding of TGFBIp to integrins activates the NF-kappaB signaling pathway that induces expression of DLL1 and JAG1 in EPCs. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LFNG | down-regulates 
binding
|
JAG1 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131560 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15574878 |
Although jagged1-induced signaling was suppressed by lfng and mfng |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG1 | up-regulates
binding
|
NOTCH |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10551863 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
JAG1
- 
- 