Summary

Name RELN
Full Name Reelin
Synonyms RELN_HUMAN
Primary ID P78509
Links - -
Type protein
Relations 8
Pathways Rett syndrome
Function Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.45
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RELN 0.378
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.394
Publications: 1 Organism: Homo Sapiens
Pathways:Rett syndrome
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation RELN 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RELN 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding VLDLR 0.785
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RELN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome