Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249388 |
Thr312 |
TKMSAAGtYAWMAPE |
Cricetulus griseus |
|
pmid |
sentence |
15610029 |
We present here biochemical and biophysical evidence that MLK1 is activated by autophosphorylation in (or near) the activation loop. The activation loops of the MLK family are highly homologous, and so one might predict that the same residues would be key to their activation. Functional data presented here, however, demonstrate that the key residue for activation of MLK1, Thr312, differs from the key residue for activation of MLK3. |
|