Summary

Name EFNB1
Full Name Ephrin-B1
Synonyms EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2 | EFL3, EPLG2, LERK2
Primary ID P98172
Links - -
Type protein
Relations 3
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHB4 0.745
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHB3 0.755
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHB1 0.822
Publications: 1 Organism: Homo Sapiens