| + |
Corticotropin | up-regulates activity 
binding
|
MC2R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268616 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 20371771 |
Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP). |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Tissue: |
Adrenal Gland |
| + |
MRAP2 | up-regulates activity
binding
|
MC2R |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252361 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 19329486 |
We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling.We have previously identified MRAP as an accessory protein for MC2R, required for receptor trafficking to the cell surface and the formation of a functional MC2R. Here we have identified MRAP2 as a homologue of MRAP. Like MRAP, MRAP2 is able to support MC2R cell-surface expression, producing a functional ACTH-responsive receptor. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
MC2R | up-regulates quantity 
|
cortisol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268621 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Adrenal Gland |
| + |
AGRP | down-regulates activity 
binding
|
MC2R |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MC2R | up-regulates activity
binding
|
GNAS |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268694 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ASIP | down-regulates activity
binding
|
MC2R |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20371771 |
The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and α, β, and γ melanocyte–stimulating hormone (MSH), which are derived from the proopiomelanocortin precursor protein, and two inverse agonists, agouti and agouti-related proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MRAP | up-regulates activity
binding
|
MC2R |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252360 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 19329486 |
We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling.We have previously identified MRAP as an accessory protein for MC2R, required for receptor trafficking to the cell surface and the formation of a functional MC2R. Here we have identified MRAP2 as a homologue of MRAP. Like MRAP, MRAP2 is able to support MC2R cell-surface expression, producing a functional ACTH-responsive receptor. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
POMC | up-regulates activity
binding
|
MC2R |
0.777 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268615 |
|
|
Cricetulus griseus |
|
| pmid |
sentence |
| 20371771 |
Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3',5'-monophosphate (cAMP). |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| Tissue: |
Adrenal Gland |
3.0
MC2R
- 
- 