3.0
Summary
| Name |  FKBP4View Modifications |
| Full Name | Peptidyl-prolyl cis-trans isomerase FKBP4 |
| Synonyms | PPIase FKBP4, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase | FKBP52 |
| Primary ID | Q02790 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A1 | down-regulates activity 
phosphorylation
|
FKBP4 | 0.347 |
| Publications: | 1 | Organism: | In Vitro | |
| + | FKBP4 | up-regulates activity 
binding
|
AR | 0.709 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PTPN2 | down-regulates
dephosphorylation
|
FKBP4 | 0.41 |
| Publications: | 1 | Organism: | Homo Sapiens | |