| + |
NFATC1 | up-regulates quantity by expression 
transcriptional regulation
|
PLAUR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23015147 |
Inducible podocyte-specific expression of constitutively active NFATc1 increased podocyte uPAR expression by binding to the Plaur gene promoter (encoding uPAR) in chromatin immunoprecipitation assays. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PLAUR | up-regulates activity
binding
|
KRT1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251880 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14691569 |
Cytokeratin 1 binds to both gC1qR and u-PAR. Our data suggest that formation of HK (and Factor XII) binding sites along endothelial cell membranes consists of bimolecular com-plexes of gC1qR-cytokeratin 1 and u-PAR-cytokeratin 1, with gC1qR binding being favored. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAUR | up-regulates activity
binding
|
ITGB3 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253333 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27383564 |
Recent evidence suggests that the activation of b3 integrin in podocytes mediates uPAR-induced cellular events leading to proteinuria |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Focal segmental glomerulosclerosis |
| + |
PLAU | up-regulates
binding
|
PLAUR |
0.888 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144306 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16456079 |
The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLAUR
- 
- 