| + |
CUL3 | down-regulates quantity by destabilization 
ubiquitination
|
HSF2 |
0.331 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239129 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 19768582 |
Here we show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-dependent ubiquitination and degradation of HSF2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HSF2 | up-regulates quantity by expression 
transcriptional regulation
|
HSPA6 |
0.345 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254478 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12813038 |
These experiments suggest that HSF2 is involved in the stress response, but unlike the ubiquitous HSF1 operates in a cell-line specific manner through differential expression of alternatively spliced isoforms. Curiously, HSF2A could not be activated by heat shock in cells deficient in functional HSF1 and required the expression of HSF1 for heat induction of the hsp70B gene in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PCGF2 | down-regulates activity
sumoylation
|
HSF2 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226245 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 18211895 |
MEL-18, in contrast to the polycomb protein PC2/CBX4, in which SUMO E3 activity stimulates sumoylation of certain proteins, actually functions like an anti-SUMO E3 protein, interacting with both HSF2 and the SUMO E2 UBC9 but acting to inhibit UBC9 activity and thereby decreasing sumoylation of a target protein, in this case that of HSF2. sumoylation of HSF2 is up-regulated during mitosis and is important for the interaction of this factor with a subunit of the condensin complex during the bookmarking process |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HSF2
- 
- 