Summary

Name AKR1C1
Full Name Aldo-keto reductase family 1 member C1
Synonyms 20-alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 1.1.1.149, Chlordecone reductase homolog HAKRC, Dihydrodiol dehydrogenase 1/2, DD1/DD2, High-affinity hepatic bile acid-binding protein, HBAB, Indanol dehydrogenase, 1.1.1.112, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, 1.3.1.20 | DDH, DDH1
Primary ID Q04828
Links - -
Type protein
Relations 1
Inhibitors hexestrol
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids (PubMed:19218247). Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH (PubMed:14672942). Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens (PubMed:10998348). May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate (PubMed:19218247). Displays affinity for bile acids (PubMed:8486699).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition AKR1C1 0.8
Publications: 1 Organism: Homo Sapiens