Summary

Name MFGE8
Full Name Lactadherin
Synonyms Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1 |
Primary ID Q08431
Links - -
Type protein
Relations 10
Function Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation TNF 0.319
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOCS3 0.358
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png STAT3 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding Av/b3 integrin 0.504
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL1B 0.269
Publications: 1 Organism: Mus Musculus
+ down-regulates img/indirect_inhibition.png Fibrosis 0.7
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/indirect_inhibition.png NfKb-p65/p50 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png GRK2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png p38 0.249
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding Av/b5 integrin 0.524
Publications: 1 Organism: Rattus Norvegicus