| + |
NFIA | up-regulates quantity 
transcriptional regulation
|
ROBO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268893 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
NEUROD1 |
0.29 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268890 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity by expression
transcriptional regulation
|
MYOG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263983 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity 
transcriptional regulation
|
ID3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268873 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
ANOS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268872 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
FOXO6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268875 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
GAS6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268876 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
EPHA8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268896 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
EPHA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268894 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
NEUROD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268891 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
EPHA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268895 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263982 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
ETV5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268874 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TFAP4 | up-regulates activity
binding
|
NFIA |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226586 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 19505873 |
We also observed moderately increased recruitment of CTCF, HDAC1, and SP1 by the full-length AP-4 onto the WT DNA beads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIA | down-regulates quantity
transcriptional regulation
|
WNT5A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268877 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
By integrating transcriptomic profiling (RNA-seq) of Nfia- and Nfix-deficient GNPs with epigenomic profiling (ChIP-seq against NFIA, NFIB and NFIX, and DNase I hypersensitivity assays), we reveal that these transcription factors share a large set of potential transcriptional targets, suggestive of complementary roles for these NFI family members in promoting neural development |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
SLIT1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268892 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
RBFOX3 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268911 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 31838646 |
For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NFIA | up-regulates quantity
transcriptional regulation
|
NFIX |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268871 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29106906 |
We report that, in the absence of Nfia or Nfib, there is a marked reduction in the spinal cord expression of NFIX, and that NFIB can transcriptionally activate Nfix expression in vitro. These data demonstrate that NFIX is part of the downstream transcriptional program through which NFIA and NFIB coordinate gliogenesis within the spinal cord. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
NFIA
- 
- 