| + |
TIAM1 | up-regulates 
|
RAC1 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167073 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
SMO | up-regulates 
binding
|
TIAM1 |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199192 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 23074268 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167070 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20654717 |
This latter work suggested that inactive smo prevents rac1 activation by interacting with the rac guanine nucleotide exchange factor (gef) t-lymphoma invasion and metastasis 1 (tiam1). This smo-tiam1 complex dissociates upon shh-mediated activation of smo, thus allowing tiam1 to activate rac1 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
TIAM1 | up-regulates
binding
|
RAC1 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12393875 |
Lpa-induced rac activation requires tiam1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates
phosphorylation
|
TIAM1 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102354 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12810717 |
Tiam1 cooperated with src to induce activation of rac1 in vivo and the formation of membrane ruffles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R9B | up-regulates quantity
binding
|
TIAM1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269175 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 12531897 |
Spinophilin binding promotes the plasma membrane localization of Tiam1 and enhances the ability of Tiam1 to activate p70 S6 kinase. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
TIAM1 | up-regulates activity
guanine nucleotide exchange factor
|
RAC1 |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260577 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TIAM1
- 
- 