| Name
|
 CHAF1A
|
| Full Name |
Chromatin assembly factor 1 subunit A |
| Synonyms |
CAF-1 subunit A, Chromatin assembly factor I p150 subunit, CAF-I 150 kDa subunit, CAF-I p150, hp150 | CAF, CAF1P150 |
| Primary ID |
Q13111 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. |
3.0
transcriptional regulation