Summary

Name TARDBP
Full Name TAR DNA-binding protein 43
Synonyms TDP-43 | TDP43
Primary ID Q13148
Links - -
Type protein
Relations 9
Function RNA-binding protein that is involved in various steps of RNA biogenesis and processing (PubMed:23519609). Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs (PubMed:23519609, PubMed:24240615, PubMed:24464995). In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases (PubMed:21358640, PubMed:29438978). Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts (PubMed:28794432). Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening (PubMed:30520513). In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (PubMed:23398327, PubMed:19765185). Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (PubMed:19760257). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png binding TARDBP 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain
+ down-regulates activity img/indirect_inhibition.png relocalization TARDBP 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png post transcriptional regulation DICER1 0.388
Publications: 1 Organism: Drosophila Melanogaster
+ down-regulates activity img/indirect_inhibition.png relocalization TARDBP 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png post transcriptional regulation HNRNPA1 0.415
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation GSK3B 0.272
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png Protein_aggregates 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding TARDBP 0.607
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding TARDBP 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain