Summary

Name FKBP5
Full Name Peptidyl-prolyl cis-trans isomerase FKBP5
Synonyms PPIase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, FKBP-51, 54 kDa progesterone receptor-associated immunophilin, Androgen-regulated protein 6, FF1 antigen, FK506-binding protein 5, FKBP-5, FKBP54, p54, HSP90-binding immunophilin, Rotamase | AIG6, FKBP51
Primary ID Q13451
Links - -
Type protein
Relations 5
Pathways Rett syndrome
Function Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation FKBP5 0.315
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ down-regulates img/direct_inhibition.png binding NR3C1 0.737
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png YY1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ up-regulates quantity by expression img/direct-activation.png catalytic activity CD274 0.2
Publications: 1 Organism: Homo Sapiens