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Summary
| Name |  TUBB3
|
| Full Name | Tubulin beta-3 chain |
| Synonyms | Tubulin beta-4 chain, Tubulin beta-III | TUBB4 |
| Primary ID | Q13509 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Inhibitors | ixabepilone |
| Function | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). |
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