Summary

Name CAMK1
Full Name Calcium/calmodulin-dependent protein kinase type 1
Synonyms CaM kinase I, CaM-KI, CaM kinase I alpha, CaMKI-alpha
Primary ID Q14012
Links - -
Type protein
Relations 18
Function Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation EIF4G3 0.483
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPME1 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HDAC5 0.429
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation NUMB 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GCM1 0.396
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KRT18 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF1 0.504
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation DNM1L 0.337
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS1 0.338
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation SYN1 0.576
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CDKN1B 0.31
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CAMK1 0.422
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation CAMK1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CAMK1 0.424
Publications: 1
+ down-regulates quantity img/direct_inhibition.png ubiquitination CAMK1 0.485
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png CAMK1 0.296
Publications: 1 Organism: Homo Sapiens