Summary

Name GRB7
Full Name Growth factor receptor-bound protein 7
Synonyms B47, Epidermal growth factor receptor GRB-7, GRB7 adapter protein
Primary ID Q14451
Links - -
Type protein
Relations 4
Function Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding GRB7 0.547
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RND1 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB7 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB7 0.561
Publications: 1 Organism: Homo Sapiens