| + |
all-trans-retinoic acid | down-regulates quantity by repression 
transcriptional regulation
|
HNF4G |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254444 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 9792724 |
Retinoic acid mediates down-regulation of the alpha-fetoprotein gene through decreased expression of hepatocyte nuclear factors. The levels of HNF1 and HNF4 mRNA were also decreased following RA treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4G | up-regulates quantity by expression 
transcriptional regulation
|
AFP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254442 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 9792724 |
AFP promoter-chloramphenicol acetyltransferase transient transfection assays demonstrated that the level of HNF1 had a direct impact on basal transcription as well as RA-mediated down-regulation of the AFP gene, and that co-transfection of HNF1 and HNF4, but not transfection of either factor alone, reversed the RA-mediated inhibition. Taken together these data point to an interaction among the RA, HNF1, and HNF4 signals, which is reflected in decreased expression of AFP. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4G | up-regulates quantity by expression
transcriptional regulation
|
AKR1C4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240013 |
|
|
Homo sapiens |
ACHN Cell |
| pmid |
sentence |
| 2044952 |
Hepatocyte nuclear factor (HNF)-4_/_, HNF-1_, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene. HNF-4_ is a necessary factor for the activation of the human DD4 gene. is much higher than that of vHNF-1-C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4G | up-regulates quantity by expression 
transcriptional regulation
|
HAS2 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261626 |
|
|
Homo sapiens |
UM-UC-3 Cell |
| pmid |
sentence |
| 23896584 |
Transcription was activated by HNF4G in reporter assays using the promoter/enhancer region of the HAS2 gene. The endogenous expression of the HAS2 gene was suppressed by knockdown of HNF4G. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HNF4G
- 
- 