Summary

Name TRADD
Full Name Tumor necrosis factor receptor type 1-associated DEATH domain protein
Synonyms TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain
Primary ID Q15628
Links - -
Type protein
Relations 17
Pathways Death Receptor Signaling, Mitochondrial Control of Apoptosis, Macrophage: TNF alpha, NF-KB Canonical, TNF alpha, Inhibition of Apoptosis, Alzheimer Disease
Function The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding FADD 0.98
Publications: 2 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF alpha
+ up-regulates activity img/direct-activation.png binding TRAF2 0.98
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Pathways:Inhibition of Apoptosis, Macrophage: TNF alpha, NF-KB Canonical, TNF alpha
+ up-regulates img/direct-activation.png binding TRAF1 0.85
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRADD 0.86
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Alzheimer Disease, Death Receptor Signaling, Inhibition of Apoptosis, Macrophage: TNF alpha, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF alpha
+ up-regulates activity img/direct-activation.png binding RIPK1 0.99
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling, Macrophage: TNF alpha, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF alpha
+ down-regulates activity img/direct_inhibition.png binding TRADD
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TRADD 0.65
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TRAF5 0.73
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BIRC2 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP8 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF alpha
+ up-regulates img/direct-activation.png binding TRADD 0.81
Publications: 1 Organism: Homo Sapiens