Summary

Name ITSN1
Full Name Intersectin-1
Synonyms SH3 domain-containing protein 1A, SH3P17 | ITSN, SH3D1A
Primary ID Q15811
Links - -
Type protein
Relations 5
Function Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed:11584276, PubMed:29887380). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (PubMed:11584276). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (PubMed:29887380). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (PubMed:22648170). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways. In chromaffin cells, required for normal exocytosis of catecholamines. Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (By similarity). Inhibits ARHGAP31 activity toward RAC1 (PubMed:11744688).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.839
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDC42 0.839
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding AP-2/clathrin vescicle 0.558
Publications: 1
+ up-regulates activity img/direct-activation.png binding ITSN1 0.638
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png relocalization ITSN1 0.2
Publications: 1 Organism: Homo Sapiens