| + |
C3AR1 | up-regulates 
|
Vascular_Permeability |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263458 |
|
|
|
|
| pmid |
sentence |
| 10984054 |
The anaphylatoxins C3a and C5a are liberated as activation byproducts and are potent pro-inflammatory mediators that bind to specific cell surface receptors and cause leukocyte activation, smooth muscle contraction and vascular permeability |
|
| Publications: |
1 |
| Pathways: | Complement Signaling |
| + |
C3AR1 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263472 |
|
|
Homo sapiens |
HMC-1 Cell |
| pmid |
sentence |
| 9108406 |
In summary, these findings indicate that C3a and C5a serve as chemotaxins for human mast cells. Anaphylatoxin-mediated recruitment of mast cells might play an important role in hypersensitivity and inflammatory processes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C3 | up-regulates activity 
binding
|
C3AR1 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263451 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8765043 |
A cDNA clone encoding the human C3a anaphylatoxin receptor (C3aR) was isolated from a pcDNAI/Amp expression library prepared from U-937 cells|The cDNA clone contained an insert of 4.3 kbp and was able to confer to transfected human HEK-293 cells the capacity to bind specifically iodinated human C3a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
| + |
C3AR1 | up-regulates
|
Chemotaxis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9108406 |
We report here that the anaphylatoxins C3a and C5a are chemotactic factors for the human mast cell line HMC-1, human cord blood-derived mast cells (CBMC) and cutaneous mast cells in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Complement Signaling |
3.0
C3AR1
- 
- 