Summary

Name NFE2
Full Name Transcription factor NF-E2 45 kDa subunit
Synonyms Leucine zipper protein NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2 |
Primary ID Q16621
Links - -
Type protein
Relations 7
Function Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFE2 0.421
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBE1 0.476
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBB 0.491
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBG1 0.506
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBG2 0.508
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png ubiquitination NFE2 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HBD 0.36
Publications: 1 Organism: Mus Musculus