Summary

Name ARHGAP11B
Full Name Inactive Rho GTPase-activating protein 11B
Synonyms Protein FAM7B1, Rho-type GTPase-activating protein 11B | FAM7B1
Primary ID Q3KRB8
Links - -
Type protein
Relations 2
Function Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP)

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein CDC42 0.462
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RHOA 0.475
Publications: 1 Organism: Homo Sapiens