| + |
ESR1 | up-regulates quantity by expression 
transcriptional regulation
|
GREB1 |
0.701 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254074 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 17666587 |
Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells. . GREB1 (gene regulated by estrogen in breast cancer 1) is an ER target gene that regulates estrogen-induced proliferation in breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GREB1 | down-regulates activity 
binding
|
SMAD2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265884 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 31462641 |
GREB1 is localized to the nucleus where it binds Smad2/3 in a competitive manner with p300 and inhibits TGFβ signaling, thereby promoting HepG2 HB cell proliferation. Binding of GREB1 to Smad2/3 inhibits transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCOA6 | up-regulates quantity by expression 
transcriptional regulation
|
GREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265883 |
|
|
Homo sapiens |
Ishikawa Cell |
| pmid |
sentence |
| 31744881 |
Herein, using growth-regulating estrogen receptor binding 1 (GREB1) as an ERα target gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for estradiol (E2)/ERα-activated GREB1 transcription. We found that NCOA6 associates with the GREB1 promoter and enhancer in an E2-independent manner and that NCOA6 knockout reduces chromatin looping, enhancer-promoter interactions, and basal GREB1 expression in the absence of E2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GREB1 | down-regulates activity
binding
|
SMAD3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265885 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 31462641 |
GREB1 is localized to the nucleus where it binds Smad2/3 in a competitive manner with p300 and inhibits TGFβ signaling, thereby promoting HepG2 HB cell proliferation. Binding of GREB1 to Smad2/3 inhibits transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GREB1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30154312 |
GREB1 is an early estrogen-responsive gene, and its expression is correlated with estrogen levels in breast cancer patients. Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AIP | down-regulates quantity by repression 
transcriptional regulation
|
GREB1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253735 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21984905 |
We show that XAP2 is recruited to the promoter of ERα regulated genes like the breast cancer marker gene pS2 or GREB1 and negatively regulate the expression of these genes in MCF-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GREB1
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