Summary

Name FBXO38
Full Name F-box only protein 38
Synonyms Modulator of KLF7 activity homolog, MoKA
Primary ID Q6PIJ6
Links - -
Type protein
Relations 1
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ FBXO38up-regulates activity img/direct-activation.png binding KLF7 0.603
Publications: 1 Organism: Chlorocebus Aethiops