Summary

Name PACS1
Full Name Phosphofurin acidic cluster sorting protein 1
Synonyms PACS-1 | KIAA1175
Primary ID Q6VY07
Links - -
Type protein
Relations 1
Function Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PACS1 0.567
Publications: 1 Organism: Mus Musculus