3.0
Summary
| Name |  CREB3L2
|
| Full Name | Cyclic AMP-responsive element-binding protein 3-like protein 2 |
| Synonyms | cAMP-responsive element-binding protein 3-like protein 2, BBF2 human homolog on chromosome 7 | BBF2H7 |
| Primary ID | Q70SY1 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). |
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cleavage