Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nima-related protein kinase 12a | JCK, NEK12A
Primary ID
Q86SG6
Links
- -
Type
protein
Relations
1
Function
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Multimerization and autophosphorylation of Nek8 are important for its activation.Our data suggests that one site for Nek8 autophosphorylation may be Thr-210 within the activation loop.