Summary

Name PNPLA6
Full Name Patatin-like phospholipase domain-containing protein 6
Synonyms Patatin-like phospholipase domain-containing protein 6 | NTE
Primary ID Q8IY17
Links - -
Type protein
Relations 2
Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584).

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Relations

Regulator Mechanism target score ℹ
+ PNPLA6up-regulates quantity img/direct-activation.png chemical modification 2-(((R)-2,3-Dihydroxypropyl)phosphoryloxy)-N,N,N-trimethylethanaminium 0.8
Publications: 1 Organism: Homo Sapiens
+ PNPLA6down-regulates quantity img/direct_inhibition.png chemical modification Lysophosphatidylcholine 0.8
Publications: 1 Organism: Homo Sapiens