Summary

Name IFNL3
Full Name Interferon lambda-3
Synonyms IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C | IL28B, IL28C, ZCYTO22
Primary ID Q8IZI9
Links - -
Type protein
Relations 2
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding IFNLR1 0.842
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding IL10RB 0.84
Publications: 1 Organism: Homo Sapiens