Summary

Name SFRP1
Full Name Secreted frizzled-related protein 1
Synonyms FRP-1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2 | FRP, FRP1, SARP2
Primary ID Q8N474
Links - -
Type protein
Relations 5
Pathways WNT Signaling, WNT/FLT3
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SFRP1 0.368
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3
+ down-regulates img/direct_inhibition.png binding Wnt 0.786
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3
+ down-regulates img/direct_inhibition.png binding WNT1 0.776
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling
+ down-regulates img/direct_inhibition.png binding WNT4 0.723
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney