Summary

Name SIRT6
Full Name NAD-dependent protein deacetylase sirtuin-6
Synonyms Regulatory protein SIR2 homolog 6, SIR2-like protein 6 | SIR2L6
Primary ID Q8N6T7
Links - -
Type protein
Relations 5
Pathways Circadian clock
Function NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png deacetylation TNF 0.317
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CLOCK/BMAL1 0.373
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png binding SREBF1 0.377
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/direct-activation.png SIRT6 0.7
Publications: 1 Organism: Homo Sapiens