Summary

Name ACVR1C
Full Name Activin receptor type-1C
Synonyms Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7 | ALK7
Primary ID Q8NER5
Links - -
Type protein
Relations 2
Inhibitors SB 505124
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding ACVR1C 0.619
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ACVR1C 0.8
Publications: 1 Organism: Homo Sapiens