Summary

Name LFNG
Full Name Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Synonyms O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Primary ID Q8NES3
Links - -
Type protein
Relations 10
Function Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding NOTCH2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH2 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LFNG
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png glycosylation, binding NOTCH1 0.11
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png binding JAG1 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DLL3 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DLL1 0.41
Publications: 1 Organism: Homo Sapiens