Summary

Name DOT1L
Full Name Histone-lysine N-methyltransferase, H3 lysine-79 specific
Synonyms DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 | KIAA1814, KMT4
Primary ID Q8TEK3
Links - -
Type protein
Relations 15
Pathways Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
Function Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png methylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png methylation H3-4 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png methylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DOT1L 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding MYC 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MEIS1 0.416
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYCBP2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MCL1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HECTD4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DOT1L 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HOXA9 0.466
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding DOT1L 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding DOT1L 0.2
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML